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Republicans have so far spurned most of Democrats' demands to rein in federal agents carrying out President Trump's immigration crackdown, threatening a homeland security funding bill ahead of a Friday deadline.
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The Maine Republican is one of her party's most vulnerable senators, but she has held off Democratic challenges before.
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Some hard-line House Republicans have balked at the agreement Senate Democrats struck with President Trump to fund the government, complicating its path to enactment.
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