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Protesters ignored threats of severe punishment from Iran's leaders and warnings from rights groups about undocumented killings as they poured out onto the streets of cities across the country late Friday
The largest demonstrations in years have left at least 48 protesters dead, human rights groups say. Trump told reporters on Friday that Iran was in "big trouble'.
Iranian protesters shouted and marched through the streets into Friday morning after a call by the country's exiled crown prince for demonstrations, despite Iran's theocracy cutting off the nation from the internet and international telephone calls.
Iran's Supreme Leader, Ayatollah Ali Khamenei, said the protesters were "a bunch of vandals" trying to please President Donald Trump, before issuing a warning that the Islamic Republic will not back down.