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And what stopped an agreement?
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Trump said the U.S. blockade will stop Iran from policing the strait and benefiting economically while the rest of the world suffers from its closure.
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Before departing Pakistan without a deal, Vice President JD Vance said the U.S. remains open to diplomacy only if Iran takes "our final and best offer."
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The health secretary says the UK - which is not involved in the talks - wants to see a deal that ends Iran's nuclear ambitions.
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Vice President JD Vance and Iranian officials both said significant differences remain in the quest for a deal that could bring a more permanent end to the war, though the fragile two-week ceasefire remains in place.
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Iran sees American demands as reaching far beyond what it achieved in war. Tehran is gambling that it can withstand further bombardment more than Washington is willing to sustain economic chaos, experts say.
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The lack of a breakthrough after 21 hours of negotiations leaves the Trump administration facing several unpalatable options.
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Iranian officials said that while Iran had approached the negotiations in good faith, the U.S. team had failed to gain the Iranian delegation's trust.
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The United States and Iran failed to reach an agreement after a day of highly anticipated face-to-face peace talks, Washington's lead negotiator Vice President J.D. Vance announced on Sunday.
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Israel's campaign targeting Hezbollah in Lebanon has been a source of tension in the U.S.-Iran cease-fire. Israeli and Lebanese officials plan to meet for rare talks in Washington this week.
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Vice President JD Vance is leading the highest level of face-to-face engagement between leaders of the United States and Iran in decades.
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Meanwhile, Israel pressed ahead with strikes in Lebanon even as Iran conditioned talks on a pause to fighting there.
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