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Patrick Mahomes threw the 200th touchdown pass of his career, reaching the milestone in his 84th game to break Dan Marino's NFL record.
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The Braves homered twice to tie the major league season record of 307 but lost their regular-season finale 10-9 to the Nationals.
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The 49ers' Christian McCaffrey had 177 yards from scrimmage, scored four times and set a franchise record for most consecutive games with at least one touchdown (13, including playoffs) in the 35-16 win over the Cardinals.
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Veteran edge rusher Khalil Mack had a franchise-record six sacks, spurred on by a late hit by Raiders DT Jerry Tillery, a former Charger.
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Atlanta's Kevin Pillar hammered a 3-1 pitch off Chicago Cubs starter Justin Steele into the left field stands in the sixth inning on Tuesday for the Braves' 300th home run this season, as the club chases the record of 307, set by the 2019 Minnesota Twins.
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