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The bus was travelling between Moscow and Simferopol, in Russian-occupied Crimea, an official says.
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Russian missile and drone attacks killed civilians across Ukraine overnight, in one of Moscow's largest assaults in recent months.
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More than a dozen people were killed and hundreds more inured after an overnight barrage of Russian missiles and drones targeted the Ukrainian capital. Russia had previously warned that it intended "systematic strikes" on targets in Kyiv linked to Ukraine's military, urging foreigners to leave.
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