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Attacks on Saturday injured dozens in Arad and Dimona, two cities closest to Israel's main nuclear research facility.
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In Lebanon, Iran ally Hezbollah has plunged into a battle with Israel that its rank and file has embraced as existential. Yet the regional conflict involves far larger powers with much higher stakes, and how Hezbollah emerges and what it achieves might be out of its hands.
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Treasury Secretary Scott Bessent defended strikes on Iran's infrastructure since the U.S and Israel's joint operation began, saying "sometimes you have to escalate to de-escalate."
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The BBC's Sebastian Usher reports from Dimona in southern Israel, which was hit by an Iranian missile.
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Iran launched missiles at two southern Israeli cities that lie close to the country's main nuclear research center, while President Trump gave Iran 48 hours to reopen the Strait of Hormuz.
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Israel is investigating how ballistic missiles got through the country's sophisticated air defences.
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Iran and Israel traded attacks on Saturday as the war in the Middle East escalated into a dangerous new direction at the start of its fourth week.
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In an alarming escalation during the U.S. war with Iran, nuclear sites have been targeted after Iran says a uranium enrichment complex was attacked. In response, an Iranian missile struck a town in Israel that's home to a major nuclear facility, injuring dozens of people. NBC News' Raf Sanchez reports from Beirut.
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An Iranian missile wounded dozens in Dimona, a city believed to house Israel's nuclear weapons program, as Iran showed no signs of backing down.
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After weeks of escalation, can diplomacy end the conflict between Iran, the US and Israel? NPR's Adrian Ma poses that question to former Iranian diplomat Hossein Mousavian.
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