The largest demonstrations in years have left at least 48 protesters dead, human rights groups say. Trump told reporters on Friday that Iran was in "big trouble'.
The confrontations over the last four months have left two people dead and prompted criticism of federal agencies for allowing officers to open fire on moving vehicles.
Protests broke out in several cities across Iran on Thursday despite an ongoing violent crackdown by security forces that has left dozens dead and led authorities to shut down the internet nationwide in an attempt to stifle the unrest