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The layoffs set up a potential battle with a federal judge who blocked previous efforts by Kari Lake, a fierce Trump ally, to restructure the agency.
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Lawyers for the administration told a court it should be "highly deferential" to the president when it comes to firing a Federal Reserve governor "for cause."
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Lawyers for the agency's chief, Susan Monarez, insist that the impasse with Health Secretary Robert F. Kennedy Jr. can only be resolved by President Trump.
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