Major Weight Loss and Knee-Pain Relief Seen With New Eli Lilly Drug The New York TimesEli Lilly's next-generation obesity drug delivers strong weight loss, reduces knee pain in late-stage trial cnbc.comEli Lilly Reports Dramatic Weight Loss in Next-Gen Obesity-Drug Trial The Wall Street JournalLilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief